Formation of an N-nitrosamine by oxidation |
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| Authors: | G W Harrington J Eshraghi H M Pylypiw R Kozeniauskas J P Gillespie |
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| Affiliation: | 1. Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, 21201, USA;2. Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, 20993, USA |
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| Abstract: | ![]()
Tolazamide, an antidiabetic drug, was found to produce N-nitrosohexamethyleneimine (NHM) upon exposure to an oxidizing agent and in the absence of a nitrosating agent. The oxidizing agents were either hydrogen peroxide or oxygen. |
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