食管癌患者微创术后合并肺部感染的危险因素Meta分析

目的 系统评价食管癌患者微创术后发生肺部感染的危险因素。方法 系统检索PubMed、The cochrane Library、Embase、CNKI、VIP和WanFang Data数据库，搜集有关食管癌患者微创术后肺部感染危险因素的研究，检索时限2016年1月至2021年1月。由两名研究者独立筛选文献，提取资料并进行偏倚风险评价，使用RevMan 5.3软件进行Meta分析。结果 共纳入10个研究，包括2176例患者。Meta分析结果显示:年龄（OR=3.21，95% CI=2.26~4.56）、吸烟史（OR=4.70，95% CI=2.97~7.43）、COPD（OR=3.34，95% CI=2.52~4.70）、糖尿病（OR=3.33，95% CI=2.65~4.18）、低蛋白血症 (OR=2.62，95% CI=2.00~3.43）、手术时间（OR=3.18，95% CI=1.57~6.47）、喉返神经损伤（OR=4.14，95% CI=2.77~6.17）、病理分期（OR=0.73，95% CI=0.55~0.96）、FEV1/FVC（OR=0.61，95% CI=0.45~0.83）、通气方式（OR=2.22，95% CI =1.43~3.46）与食管癌患者微创术后肺部感染有关。结论 高年龄、吸烟史、COPD、糖尿病、低蛋白血症、手术时间长、喉返神经损伤、病理分期高、低FEV1/FVC和单肺通气是食管癌患者微创术后肺部感染的危险因素。

Risk factors for pulmonary infection in patients with minimally invasive esophagectomy: a meta-analysis

To systematically review the risk factors of patients with pulmonary infection after minimally invasive esophagectomy. Methods PubMed, the Cochrane Library, Embase, CNKI, VIP and WanFang Data databases were electronically searched for studies on the risk factors of patients with pulmonary infection after minimally invasive esophagectomy from January 2016 to January 2021. Two reviewers independently extracted data and assessed risk of bias of included studies, then, Meta-analysis was performed by using RevMan 5 software. Results A total of 10 articles were included, including 2176 patients. The results of meta-analysis showed that age(OR=3.21, 95%CI=2.26-4.56), smoking(OR=4.70, 95%CI=2.97-7.43), COPD(OR=3.34, 95%CI=2.52-4.70), diabetes history(OR=3.33, 95%CI=2.65-4.18), hypoproteinemia(OR=2.62, 95%CI=2.00-3.43), operation time(OR=3.18, 95%CI=1.57-6.47), laryngeal nerves paralysis(OR=4.14, 95%CI=2.77-6.17), pathological stage(OR=0.73, 95%CI=0.55-0.96), FEV1/FVC(OR=0.61, 95%CI=0.45-0.83), and ventilation mode(OR=2.22, 95%CI=1.43-3.46) were associated with pulmonary infection in patients undergoing minimally invasive esophagectomy. Conclusion Current evidences show the older age, history of smoking, COPD, diabetes, hypoproteinemia, increased operation time, laryngeal nerves paralysis, higher pathological stage, lower FEV1/FVC, and single ventilation mode are risk factors of patients with pulmonary infection after minimally invasive esophagectomy.