腹腔注射细菌脂多糖加重大鼠的应激性抑郁症

目的 观察腹腔注射细菌脂多糖对大鼠应激性抑郁症的影响。方法 制备大鼠应激性抑郁症模型，采用开场实验检测大鼠的行为性抑郁，用MTT法测定淋巴细胞转化。结果 慢性应激16d，大鼠出现自主活动时间和中区逗留时间缩短、活动路程减少等抑郁性行为。腹腔注射细菌脂多糖加重大鼠的行为性抑郁，并加强应激大鼠血清对正常淋巴细胞转化的抑制作用。结论 腹腔注射细菌脂多糖加重大鼠的行为性抑郁，其原因可能与脂多糖引起的脑内炎性细胞因子的释放有关。

Effect of Intraperitoneal Injection of LPS on Behavioral Depression Induced by Chronic Stress in Rats

Objective To study the relationship between depressive severity and the effect of serum on lymphocyte proliferation in depressive rats induced by chronic stresses. Methods Depression animal model was reproduced with 8 unexpectable stressors in 16 days and the depressive behavior was measured with Open Field test.Lymphocyte proliferation was tested with MTT method. Results The depressive behavior started from day 14th after stress,reached the peak at day 21st and at least lasted to day 28th.The serum from depressive rat inhibited ConA induced lymphocyte proliferation which paralleled to depressive severity. Conclusion Chronic stress could induce depressive behavior in rats,and which is related with the inhibitory effect of serum on lymphocyte proliferation.