老年复发性结直肠癌的外科治疗

目的探讨外科手术治疗老年复发性结直肠癌的安全性和有效性。方法回顾性分析第二军医大学长海医院2000年1月至2009年6月间收治的24例老年复发性结直肠癌患者（直肠癌复发14例,结肠癌复发10例）的临床和随访资料。结果24例患者中男14例,女10例;年龄（76．9±5.3）岁。单纯局部复发15例,局部复发伴远处转移9例。予以根治性切除术15例,姑息性切除术8例：另外1例因腹腔广泛转移并累及十二指肠和胆总管而行腹腔开关术．术后接受胆总管支架置入术并化疗。7例患者（29．2％）术后出现并发症,包括肠梗阻1例,肺部感染1例,尿路感染1例,切口感染2例,腹部切口裂开1例,切口脂肪液化1例;无围手术期死亡病例。全组患者中位生存时间6个月,其中R0切除组中位生存时间33个月,1、3、5年生存率分别为71．4％、28．6％和14．3％：姑息性切除组中位生存时间为3个月,1年生存率为0;两组生存差异有统计学意义（P〈0．01）。结论只要术前认真评估病情和重视围手术期处理,对于老年复发性结直肠癌患者予以积极的根治性切除仍可获得满意疗效。

Surgical treatment of recurrent colorectal carcinoma in the elderly

Objective To evaluate the safety and efficacy of surgical treatment for recurrent colorectal carcinoma in the elderly. Methods The clinical and follow up data of 24 elderly patients with recurrent colorectal carcinoma who were treated between January 2000 and June 2009 at the Changhai hospital of the Second Military Medical University were analyzed retrospectively. Results Among the 24 patients there were 14 men and 10 women. The mean age of the patients was 76.9±5.3 years. The local recurrence was found in 15 patients. In 9 patients, both distant metastases and local recurrence were found. A total of 24 patients received operation, including radical resection in 15 patients and palliative resection in 8 patients. One patient had laparotomy only because of diffuse metastases in the abdomen and involvement of the duodenum and common bile duct. The patient received stent placement in the common bile duct and chemotherapy after the surgery. Postoperative complication occurred in 7 （29.2%） patients, which included ileus （n=1）, pulmonary infection（n=1）, urinary infection（n=1）, wound infection（n=2）, wound dehiscence （n=1）, and wound fat liquefaction（n=1）. There were no perioperative deaths. The median survival time was 6 months in the entire cohort. The median survival time was 33 months in patients undergoing radical resection, and the 1-, 3-, and 5-year survival rate was 71.4%, 28.6%, and 14.3%. The median survival time was 3 months in patients who underwent palliative resection, and the 1-year survival rate was 0. The difference between the two groups was statistically significant（P〈0.01）. Conclusion Outcomes are acceptable after radical resection for elderly patients with recurrent colorectal cancer if careful preoperative evaluation and perioperative management are performed.