|
|||||
|
|
| 十溴联苯醚对大鼠学习记忆及海马神经元影响 | |
| 引用本文： | 汤艳,李华,陈润,彭长燕,陈卉. 十溴联苯醚对大鼠学习记忆及海马神经元影响[J]. 中国公共卫生, 2011, 27(6) |
| 作者姓名： | 汤艳 李华 陈润 彭长燕 陈卉 |
| 作者单位： | 1. 泸州医学院公共卫生系环卫与劳卫教研室,四川,泸州,646000 2. 泸州医学院药学院 |
| 摘 要： | 目的 探讨十溴联苯醚(BDE-209)对成年大鼠学习记忆及海马神经元的影响.方法 将48只SD成年大鼠随机分为溶剂对照组、BDE-209低、中、高(250,500,1 000 mg/kg)剂量组,每天灌胃1次,持续30 d;用Morris水迷宫测试学习记忆,电镜观察海马神经元结构.结果 对照组和BDE-209低、中、高剂量组穿越平台次数分别为(12.63±2.48)、(9.90±1.75)、(7.26±1.48)、(4.72±1.76)次,在平台象限停留时间分别为(52.92±7.78)、(31.89±5.97)、(24.82±6.65)、(18.25±5.23)s,差异具有统计学意义(P＜0.05),平均逃避潜伏期随染毒剂量的增加明显延长(P＜0.05);与对照组比较,BDE-209染毒组海马神经元均有不同程度损害,线粒体肿胀,粗面内质网和高尔基复合体扩张、细胞核染色质异常聚集及均匀化,神经元突触结构不清楚.结论:BDE-209可致成年大鼠海马神经元结构及其功能损伤,降低学习记忆能力. |
| 关 键 词： | 十溴联苯醚 学习记忆 Morris水迷宫 海马 |
Influence of BDE-209 exposure on learning and memory and neurons in hippocampus of adult rats |
|
| TANG Yan,LI Hua,CHEN Run,et al.. Influence of BDE-209 exposure on learning and memory and neurons in hippocampus of adult rats[J]. Chinese Journal of Public Health, 2011, 27(6) | |
| Authors: | TANG Yan LI Hua CHEN Run et al. |
| Affiliation: | TANG Yan,LI Hua,CHEN Run,et al.Department of Occupational and Environmental Medicine,Luzhou University of Medical Science(Luzhou 646000,China) |
| Abstract: | Objective To explore the effects of brominated diphenyl ethers-209(BDE-209) exposure on spatial learning and memory abilities and ultramicrostructure of hippocampal neurons in adult rats.Methods Forty-eight Sprague Dawley adult rats were randomly divided into a solvent control group and three BDE-209-treated groups.The exposure groups were treated by intragastric administration of 250,500,and 1000 mg/kg BDE-209 once a day,respectively.The administration was lasted for 30 days.After the experiment,the capabi... |
| Keywords: | brominated diphenyl ethers-209 learning and memory Morris water maze hippocampus |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |