Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm |
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Authors: | J H Kehne J V Cassella M Davis |
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Institution: | (1) Ribicoff Research Facilities of the Connecticut Mental Health Center and the Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 06508 New Haven, CT, USA |
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Abstract: | Fear potentiation of the acoustic startle reflex was produced by eliciting startle responses in the presence of a light that had been previously paired with a shock. Buspirone (0.6–5.0 mg/kg) and gepirone (1.25–10.0 mg/kg), but not their common metabolite, 1-PP (0.5–40 mg/kg), produced a dose-dependent reduction of fear-potentiated startle. These doses of buspirone and gepirone slightly increased baseline startle levels. Reduction of fear-potentiated startle appears to involve supraspinal sites of action, since intraventricular but not intrathecal administration of buspirone (200 ;g) reduced fear-enhanced startle. Both buspirone and gepirone were highly efficacious in this model compared to other animal tests that are used to study anxiolytic compounds. |
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Keywords: | Buspirone Gepirone Startle Fear Conditioned fear Intrathecal |
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