Binding profile of SM-9018, a novel antipsychotic candidate |
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| Authors: | T Kato A Hirose Y Ohno H Shimizu H Tanaka M Nakamura |
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| Institution: | Research Laboratories, Sumitomo Pharmaceuticals, Co., Ltd., Osaka, Japan. |
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| Abstract: | The present study employed various receptor-binding assays to clarify the biochemical characteristics of SM-9018. SM-9018 possessed very high affinity for 5-HT2, D2 and 5-HT1A receptors (Ki = 0.61, 1.4 and 2.9 nM, respectively), and it had moderate affinity for alpha 1 and D1 receptors (Ki = 17 and 41 nM, respectively). However, SM-9018 had only negligible affinity for alpha 2, opiate, glutamate, phencyclidine, benzodiazepine and GABAA receptors. These results suggest that SM-9018 may be a novel antipsychotic agent with binding affinity for 5-HT2 and 5-HT1A receptors. |
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