血尿酸和超敏C-反应蛋白与长寿家系的关系

目的 分析血尿酸、超敏C-反应蛋白与长寿家系的关系。 方法 选取5个长寿县的90岁及以上长寿老人，并匹配选取其他年龄段的非长寿老人进行横断面调查，817名老人均接受问卷收集基本信息，空腹静脉血测定血尿酸、超敏C-反应蛋白。结果 在整个调查人群中，长寿家系血尿酸水平显著高于非长寿家系（t=2.146, P=0.016）。非长寿老人中，长寿家系高尿酸血症、高超敏C-反应蛋白患病率与非长寿家系比较差异有统计学意义（〖XC五号.EPS;P〗=11.163、5.253，P=0.001、0.022）。多因素logistic回归分析结果显示，在非长寿老人中，长寿家系患高尿酸血症的风险更高（OR=1.670，95%CI:1.054-2.646），患高超敏C-反应蛋白的风险更低（OR=0.417，95%CI:0.193-0.899）。在长寿老人中，长寿家系和非长寿家系患高尿酸血症和高超敏C-反应蛋白的风险无差别（P=0.101、0.435）。结论 一定范围的高血尿酸和低超敏C-反应蛋白可能是长寿的有益因素，并可能是长寿遗传的特征指标。

Relationship between serum uric acid,hypersensitive C-reactive protein and longevity family

Objective To analyze the relationship between serum uric acid (UA), hypersensitive C- reactive protein (hs-CRP) and longevity family. Methods Long-lived elderly people aged 90 and over in 5 longevity counties were selected, and cross-sectional surveys were conducted for non-long-lived elderly people of other ages. 817 elderly people received basic information from the questionnaire. Fasting venous blood was measured for blood uric acid and hypersensitive C- reactive protein. Results Among the survey population, the blood uric acid level of the longevity family was significantly higher than that of the non-longevity family (t=2.146, P=0.016). Among non-long-lived elderly people, the prevalence of hyperuricemia and hypersensitivity C-reactive protein in longevity families was statistically significant compared with non-longevity families. (χ2=11.163, 5.253, P=0.001, 0.022). Multivariate logistic regression analysis showed that long-lived families had a higher risk of hyperuricemia ［OR=1.670, 95%CI(1.054-2.646)］ among non-long-lived elderly people, and had a lower risk of developing high-sensitivity C-reactive protein ［OR=0.417, 95%CI(0.193-0.899)］. Among long-lived elderly people, there was no difference in the risk of hyperuricemia and hypersensitivity C-reactive protein between longevity and non-longevity families (P=0.101, 0.435). Conclusion A range of hyperuricemia and low-sensitivity C-reactive protein may be beneficial factors for longevity and may be a characteristic indicator of longevity inheritance.