| 肝移植术后丙肝复发抗病毒治疗患者持续病毒应答影响因素分析 |
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| 引用本文： | 李姗霓,孙丽莹,朱志军,朱理玮. 肝移植术后丙肝复发抗病毒治疗患者持续病毒应答影响因素分析[J]. 山东医药, 2010, 50(50) |
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| 作者姓名： | 李姗霓 孙丽莹 朱志军 朱理玮 |
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| 作者单位： | 天津医科大学总医院 天津市第一中心医院 |
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| 摘 要： | 目的分析肝移植术后丙肝复发抗病毒治疗患者产生持续病毒应答(SVR)的影响因素。方法回顾性分析2003～2009年39例肝移植术后丙肝复发并进行抗病毒(聚二乙醇干扰素和利巴韦林)治疗的患者的临床资料。结果本组中21例因不良反应停药,18例完成全疗程规范治疗,疗程25～105周;有4例(22.22%)获得SVR,其平均治疗周期是57周。统计分析显示,非ⅠB型基因(P=0.023)、治疗前丙肝病毒载量<10~6 copies/ml(P=0.044)以及早期病毒应答(EVR)(P=0.019)与SVR的获得有关。结论非ⅠB基因型、低水平HCV RNA和EVR是肝移植后丙肝复发抗病毒治疗产生SVR的影响因素。
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| 关 键 词： | 肝移植 丙肝 抗病毒治疗 持续病毒应答 |
Relative factors analysis of sustained viral responses in patients with recurrent hepatitis C infection after liver transplantation |
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| LI Shan-ning,SUN Li-ying,ZHU Zhi-jun,ZHU Li-wei. Relative factors analysis of sustained viral responses in patients with recurrent hepatitis C infection after liver transplantation[J]. Shandong Medical Journal, 2010, 50(50) |
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| Authors: | LI Shan-ning SUN Li-ying ZHU Zhi-jun ZHU Li-wei |
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| Affiliation: | 1 Tianjin Medical University General Hospital; Tianjin 300192; P.R.China); |
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| Abstract: | Objective To analyz the relative factors analysis of sustained viral responses(SVR) in patients with recurrent hepatitis C infection after liver transplantation.Methods Retrospective analyed The clinical data of 39 patients with hepatitis C recurrence after liver transplantation and antiviral treatment were analized retrospectively.Results 21 patients treatment was discontinued due to side effects,18 remaining patients completed a cycle of therapy for 25～105 weeks.The mean treatment duration was 57 weeks w... |
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| Keywords: | liver transplantation hepatitis C recurrence antiviral therapy sustained viral responses |
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