肺心汤对慢性肺心病患者一氧化氮、内皮素及肾上腺髓质素的影响

目的：探讨复方中药制剂肺心汤治疗肺心病急性发作期的疗效及对一氧化氮（NO）、内皮素－1（ET－1）、肾上腺髓质素（ADM）的影响。方法：将46例肺心病发作期患者随机分为肺心汤治疗组和西药治疗组，各23例，分别给予肺心汤和常规西药（抗炎、解痉、扩血管等）治疗14天，以硝酸还原酶法测血清NO含量；用放射免疫法测血浆ET－1和ADM水平，结果：肺心汤与西药治疗肺心病急性发作期临床疗效无明显差异（P＞0．05）；两组治疗后PaO2均升高，PaCO2降低（P均＜0．01），两组之间差异无显著性（P＞0．05）。但肺心汤治疗组血清NO含量较治疗前明显增加（P＜0．01），血浆ET－1、ADM则明显降低（P＜0．01），而西药治疗组治疗后NO、ET－1、ADM无明显变化，两组之间差异有非常显著性意义（P＜0．01）。结论：肺心汤治疗肺心病急性发作期具有较好的临床疗效。其可能部分通过调节患者NO、ET－1、ADM平衡而起作用。

Effects of Feixin Decoction on Nitric Oxide, Endothelin and Adrenomedullin Levels in Patients with Chronic Cor Pulmonale

Objective: To explore the clinical curative effect of a compound preparation of medicinal Feixin decoction (FXD) on treating cor pulmonale at acute stage and to study the effects of which on nitric oxide (NO), endothelin 1 (ET-1), and adrenomedullin (ADM) levels. Methods: 46 cor pulmonale at acute stage cases were divided into two groups (23 in each) randomly, which were treated with FXD and common west medicine for 14 days respectively. Serum NO level was measured by nitrate reeducates method; plasma ET-1 and ADM levels were measured by radioimmnoassay. Results: The curative effect of FXD on cor pulmonale at acute stage seemed to be same to that of common west medicine (P>0.05). The PaO 2 was increased and the PaCO 2 was decreased after treatment, there was no significant difference in both groups (P>0.05). Serum NO level was increased, but plasma ET-1 and ADM levels were lowered after FXD treatment (P<0.01). However, no changes of those indexes were detected in common west medicine group (P>0.05). Moreover, there were markedly differences in those indexes between FXD and common west medicine group (P<0.01). Conclusion: These results showed that FXD was proved to have a good clinical curative effect on treating cor pulmonale at acute stage, mechanism of which may partly regulate balance of NO, ET-1, and ADM levels.