大鼠下丘脑室旁核对脑干和脊髓的传出投射——PHA-L法研究

对24只Wistar系大鼠,用PHA-L法追踪研究了下丘脑室旁核(Pa)向脑干和脊髓的投射。 Pa向中脑中央灰质和E-W核、脑干网状结构和中缝核、蓝斑臂旁区、孤束迷走复合体、疑核和疑核周区、延髓腹侧区等脑干结构,对脊髓外侧颈核、外侧脊核、胸腰骶节中间外侧柱及中央管周围区域等部位有广泛的投射。其中向脑干和脊髓的自主神经节前神经元区、脑干调节自主活动的中枢以及儿茶酚胺能神经细胞群所在区域的投射相对丰富。本文就Pa的下行传出投射进行了讨论。认为Pa是心血管活动中枢调节的重要部位,同时认为Pa的作用不是单系统、单方面的,它在下丘脑对自主活动的中枢调节中似占据一个关键性的位置。

THE EFFERENT PROJECTIONS FROM HYPOTHALAMIC PARAVENTRICULAR NUCLEUS TO BRAINSTEM AND SPINAL CORD IN THE RAT

The efferent projections from hypothalamic paraventricular nucleus (Pa) to brainstem and spinal cord were traced anterogradely with phaseolus vulgaris leucoagglutinin(PHA-L)immunohistochemical technique in 24 Wistar rats.Widespread projections from Pa were found in brainstem structures (including central gray of midbrain, Edirger-Westphal nucleus, reticular formation and raphe nuclei of brainstem, locus coeruleus-parabrachial area, vagus solitarius complex, ambiguus nucleus and periambiguus region, ventral area of medulla), and spinal cord(including lateral cervical nucleus, lateral spinal nucleus, intermediolateral column and pericanal region). Among which, the projections to preganglionic visceral neurons of brainstem and spinal cord, to brainstem centres regulating autonomic activities, and to regions of catecholaminergic neurons were especially profuse.The efferent projections of Pa were discussed in this paper. It is believed that Pa is an important portion of central mechanism for regulating activities of heart and blood vessels, and that functions of Pa were not confined to a single system or a single aspect. It seems that Pa occupies a key position in central control of autonomic activities.