Conformational changes in the IgG molecule of lepromatous sera using laser Raman spectroscopy |
| |
| Authors: | R Kumar M M Bajaj B Swaroop |
| |
| Affiliation: | Dept. of Physics and Astrophysics, University of Delhi. |
| |
| Abstract: | In the present work we report our studies on IgG separated from the serum of lepromatous patients and non-lepromatous leprosy cases using Laser Raman Spectroscopy. Striking spectral changes in LL cases have been observed in the following special regions: (a) the amide I and III, (b) the S-S and C-S stretching (c) the skeletal bending and (d) skeletal stretching regions. These changes indicate a decrease in the amount of beta-structure and a transition towards alpha-helical conformation. |
| |
| Keywords: | |
|
