| 脑溢安对脑出血大鼠脑内含铁血红素氧合酶—1的影响 |
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| 引用本文： | 唐涛,黎杏群,等.脑溢安对脑出血大鼠脑内含铁血红素氧合酶—1的影响[J].湖南医科大学学报,2002,27(1):35-37. |
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| 作者姓名： | 唐涛 黎杏群 |
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| 摘 要： | 目的：探讨脑溢安对脑血血后含铁血红素氧保酶－1(heme oxygenase-1,HO-1）表达的影响。方法：采用胶原酶复制大鼠脑出血模型，以免疫组化法观察脑出血后脑内HO－1的表达情况，计数HO－1的阳性细胞。结果：脑出血后，模型组大鼠脑内HO－1第12h即有表达，第2d达高峰，第7d仍有表达；脑溢安在第24h即明显增强大鼠脑内HO－1表达。结论：脑出血后，脑内HO－1表达增加；脑溢安可能通过上调HO－1的表达，实现其神经元保护作用。
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| 关 键 词： | 中药 含铁血红素氧合酶－1 脑出血 动物疾病模型 大鼠 免疫组织化学 脑溢安 |
Effects of nao-yi-an granule on the expression of heme oxygenase-1 in brains of intracerebral hemorrhagic rats] |
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| Tao Tang,Tuan-lian Luo,Xing-qun Li.Effects of nao-yi-an granule on the expression of heme oxygenase-1 in brains of intracerebral hemorrhagic rats][J].Bulletin of Hunan Medical University,2002,27(1):35-37. |
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| Authors: | Tao Tang Tuan-lian Luo Xing-qun Li |
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| Institution: | Institute of Combined Traditional Chinese Medicine and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. |
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| Abstract: | OBJECTIVE: To investigate the effects of the traditional Chinese medicine complex nao-yi-an granule(NYA) on the expression of heme oxygenase-1(HO-1) in the brains of intracerebral hemorrhagic (ICH) rats. METHODS: After inducing ICH rat models with collagenase VII, we used the immunohistochemical method and HO-1 immunoreactive cell count to observe the HO-1 expression. RESULTS: Following ICH, the expression of HO-1 in the rat brains was observed at 12 h, peaking at 2 d and persisting until 7 d; and NYA could increase the expression at 24 h obviously. CONCLUSION: Expression of HO-1 increases following ICH,; upregulation of HO-1 expression may be one of the neuroprotective mechanisms of NYA. |
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