中国居民超重或肥胖、吸烟、饮酒与脑卒中关系的Meta分析

目的 探讨中国居民超重或肥胖、吸烟、饮酒与脑卒中的关系.方法 采用RevMan 4.2.9版本软件中的Meta分析,对1999-2006年国内有关研究超重或肥胖、吸烟、饮酒等因素对脑卒中关系的文献进行综合分析.结果 检索到超重或肥胖、吸烟、饮酒与脑卒中关系的文献分别有6篇、6篇、6篇;经异质性检验后,分别采用固定效应模型、随机效应模型进行OR值的合并.超重或肥胖、吸烟、饮酒对脑卒中影响的合并OR值分别为1.81(95% CI:1.40～2.35)、1.22(95% CI:1.08～1.37)和1.19(95% CI:1.03～1.38),经Z检验,Z值分别为4.52、3.24、2.36,P值均小于0.05.同时绘制漏斗图,发现图形基本呈现对称的漏斗状,这说明该类研究发表偏倚较小.结论 中国居民超重或肥胖、吸烟、饮酒均为脑卒中的危险因素.

Meta-analysis on the stroke with overweight or obesity, smoking and alcohol drinking in Chinese residents

OBJECTIVE: To study the relationship between overweight/obesity, smoking, alcohol drinking and the stroke in Chinese residents, as to providing a scientific foundation to the causal prophylaxis of stroke. METHODS: Appling a meta-analysis with software of RevMan 4.2.9 version to systematically analyze the references in dealing about the relationship between overweight/obesity, smoking, alcohol drinking and the stroke in China during 1999 to 2006. RESULTS: Six, six and six articles dealing about overweight/obesity, smoking, alcohol drinking and the stroke were searched respectively. Incorporated by fix effect model, random effect model and random effect model after the heterogeneity tests, the values of OR were 1.81 (95% CI: 1.40-2.35), 1.22 (95% CI:1.08-1.37) and 1.19 (95% CI:1.03-1.38). After Z tests, the Z values were performed with 4.52, 3.24 and 2.36 respectively (all the P values were less than 0.05). Additionally, the funnel plots were protracted and the sensibility analysis was performed. CONCLUSIONS: The publication biases were little and the results were creditable. The overweight/obesity, smoking and alcohol drinking in residents in China should be the risk factors of the stroke.