褪黑素对大鼠电针镇痛效应的影响

本实验以 5 0℃热水刺激引起的大鼠甩尾反应为痛反应指标 ,观察腹腔注射 (i p )不同剂量褪黑素 (MEL) 3 0、60、1 2 0mg/kg的镇痛效应 ,及MEL 60mg/kg对电针镇痛效应的影响。结果显示 ,i p MEL 3 0mg/kg对大鼠甩尾潜伏期无影响 ;i p MEL 60、1 2 0mg/kg均能显著延长大鼠甩尾潜伏期 ,作用随着剂量增大而增强 ;i p MEL 60mg/kg 3 0分钟后给予电针刺激 3 0分钟 ,大鼠甩尾潜伏期显著长于单纯给药组和单纯电针组 ,提示褪黑素具有镇痛作用 ,并能加强电针镇痛效应。

Effects of Melatonin on Electroacupuncture Analgesia in Rats

In order to explore the analgesic effect of melatonin and its influence on acupuncture analgesia,the present study was designed to investigate the effect induced by intraperitoneal (i. P. ) melatonin(30, 60,120 mg/kg) and melatonin (60 mg/kg) combined with electroacupuncture in rats. Antinociception was determined by tail flick lantency (TFL) to hot water at 50℃. The results showed that 30mg/kg melatonin could not influence the TFL, but 60 and 120 mg/kg melatonin could prolong the TFL, moreover, the change (%) of TFL which induced by 120 rog/kg melatonin was greater than that induced by 60 mg/kg. During melatonin combined with electroacupuncture, the change (%) of TFL was much greater than using electroacupuncture or melatonin (60 mg/kg) alone. It is suggested that melatonin has analgesic effect and it can enhance the effect of electroacupuncture analgesia.