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E-cadherin: a marker for differentiation and invasiveness in prostatic carcinoma
Authors:T. Otto  K. Rembrink  M. Goepel  M. Meyer-Schwickerath  H. Rübben
Affiliation:(1) Klinik für Urologie der Universität, Hufelandstrasse 55, D-45147 Essen, Germany
Abstract:
Summary Considerable controversy exists concerning the value of histomorphological data in the assessment of the malignant potential of prostatic carcinomas. We investigated the expression pattern of E-cadherin in human prostate at the translational level. E-cadherin is a specific epithelial cell-cell adhesion molecule which has previously been found to be expressed in well-differentiated non-invasive carcinoma cell lines but is lost in many poorly differentiated invasive cell lines. The E-cadherin expression pattern in the prostate samples was correlated with histopathological findings in the same specimens. We found strong E-cadherin expression in normal prostate and benign prostatic hyperplasia. A decrease in or loss of E-cadherin was seen in 13 of 14 locally advanced and in 8 of 9 poorly differentiated prostatic carcinomas. We conclude that downregulation of E-cadherin expression plays a role in prostate carcinogenesis and invasiveness.
Keywords:Cell-cell  adhesion molecules  Differentiation  E-cadherin  Invasiveness  Prostatic carcinoma
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