| 蛛网膜下腔再出血(附11例报告) |
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| 引用本文： | 李蕊,引华山.蛛网膜下腔再出血(附11例报告)[J].吉林大学学报(医学版),2000,26(3):225. |
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| 作者姓名： | 李蕊 引华山 |
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| 作者单位： | 吉化集团公司总医院第二医院神经内科 |
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| 摘 要： | ? Objective:To explore the molecular mechanism of G1arrest of thymocytes and splenocytes in mice induced by whole body irradiation(WBI) .Methods:Flow cytometry(FCM) and dotblotwere used to analyze MDM2 m RNA and protein expressions of thymocytes and splenocytes in Kunming mice after whole body irradiation (WBI) with x- rays.Results:The expressions of MDM2 protein of thymocytes in mice increased from 4h to 8h after 2 Gy WBI.There were no significant changes of MDM2 m RNA level of thymocytes and splenocytes from0 to48h after75m Gy or2 Gy WBI.No changes of MDM2 m RNA level were also found in thymocytes or splenocytes of mice4h after0～ 6Gy WBI.Conclusion:These results suggest that ionizing radiation could induce MDM2 protein expression and make G1arrest cells reentering cell cycle. 〔
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Effects of ionizing radiation on MDM2 m RNA and protein expressions of thymocytes and splenocytes in mice |
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| Fu Haiqing,Ju Guizhi,Luo Can,Fu Shibo.Effects of ionizing radiation on MDM2 m RNA and protein expressions of thymocytes and splenocytes in mice[J].Journal of Jilin University: Med Ed,2000,26(3):225. |
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| Authors: | Fu Haiqing Ju Guizhi Luo Can Fu Shibo |
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| Institution: | MH Radiobiology Research Unit |
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| Abstract: | |
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| Keywords: | ? ioizing radiation thymocytes splenocytes MDM2 gene |
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