|
|||||
|
|
Nerve terminal degeneration after a single injection of D-amphetamine in iprindole-treated rats: relation to selective long-lasting dopamine depletion |
|
| Authors: | G. A. Ricaurte R. W. Guillery L. S. Seiden C. R. Schuster |
| Affiliation: | Department of Pharmacological and Physiological Sciences and Psychiatry, The University of Chicago, Chicago, IL 60637 U.S.A. |
| Abstract: | A single injection of D-amphetamine has recently been shown to produce long-lasting dopamine (DA) deficits in rats pretreated with iprindole, an agent which interferes with the metabolism of amphetamine and prolongs its half-life. The basis for these persistent DA deficits has not been determined. The present results suggest that amphetamine produces prolonged DA depletions in iprindole-treated rats by destroying DA nerve terminals. |
| Keywords: | Correspondence: G.A. Ricaurte Dept. of Pharmacological and Physiological Sciences The University of Chicago Chicago IL 60637 U.S.A. |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |