子宫腺肌病组织中MCP-1含量变化及意义

[摘要]目的 探讨单核细胞趋化蛋白-1（monocyte chemoattractant protein-1，MCP-1）在子宫腺肌病发病中的作用。方法采用免疫组化法和实时荧光定量PCR法检测36例子宫腺肌病患者在位内膜、异位病灶组织中的MCP-1含量，并与相应对照组进行比较。结果 腺肌病患者不论是在位内膜，还是异位灶，MCP-1含量均高于相应正常对照组（P<0.05），异位灶组织中MCP-1含量高于在位内膜（P<0.05），而且两者具有相关性（r＝0.87，P<0.01）。结论 MCP-1可能参与了子宫腺肌病的发病过程，但具体分子机制尚需进一步研究。

Changes of monocyte chemoattractant protein-1 content in adenomyotic tissue and its significance

Objective To investigate the role of monocyte chemoattractant protein-1 (MCP-1) in the pathogenesis of adenomyosis. Methods MCP-1 was examined by immunohistochemistry method and real-time PCR in the eutopic endometrium and ectopic endometrium of 36 patients with adenomyosis, and the results were compared with those of controls. Results MCP-1 contents in the eutopic endometrium and ectopic endometrium of patients with adenomyosis were significantly higher than those of normal controls(P<0.05). The contents in ectopic endometrium tissue was significantly higher than that in eutopic endometrium tissue (P<0.05), and the contents in the two tissues were significantly correlated with each other (r=0.87, P<0.01) .Conclusion MCP-1 may be involved in the pathogenesis of adenomyosis, but the specific molecular mechanisms need further study.