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Bone marrow transplantation in chronic granulomatous disease |
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| Authors: | M. C. Calviño M. S. Maldonado E. Otheo A. Muñoz J. M. Couselo C. Burgaleta |
| Affiliation: | 1. Servicio de Pediatría, Hospital Ramón y Cajal, E-28034, Madrid, Spain 2. Department of Paediatrics, Hospital Xeral de Galicia de Santiago, Spain 3. Department of Haematology, Hospital Ramón y Cajal, Madrid, Spain |
| Abstract: | We present a 5-year-old boy with a severe form of X-linked chronic granulomatous disease and hypersensitivity to sulphamides preventing prophylaxis with trimethoprim-sulphomethoxazole. Bone marrow transplantation was performed after preconditioning with busulphan and cyclophosphamide. The immediate post-transplant period was with-out complications. Complete chimerism was demonstrated and post-transplant oxidative metabolism was normal. The patient is asymptomatic 30 months after the graft. |
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