咪达唑仑预处理减少依托咪酯所致的肌阵挛

目的观察0．015mg／kg咪达唑仑预处理对依托咪酯全麻诱导时肌阵挛的影响。方法100例择期全麻手术患者随机均分为观察组和对照组。每组50例。观察组和对照组诱导时分别静脉注射0．015mg／kg咪达唑仑和同等剂量的生理盐水后静脉注射0．3mg／kg依托咪酯。观察有无肌阵挛发生，并记录肌阵挛程度。完成记录后，两组均静脉注射4μg／kg芬太尼，1min后两组均静脉注射0．6mg／kg罗库溴铵，充分肌松后气管插管。结果观察组的50例患者中，仅5例出现轻度的肌阵挛，而对照组的50例患者中有39例发生肌挛（P〈0．01）；在对照组中注射依托咪酯后男性患者和女性患者肌事的发生率差异无显著性。结论0．015mg／kg咪达唑仑预处理可减少依托咪酯全麻诱导所致的肌阵挛。

Myoclonus after injection of etomidate: the effect of pretreatment of midazolam

Objective To study the effect of pretreatment of midazolam（0. 015 mg/kg）to reduce myoclonus after injection of etomidate. Methods 100 patients undergoing operation with general anesthesia were divided into two groups randomly with 50 cases in each group： midazolam group and control group. Before injection with etomidate（0. 3 mg/kg）,each group received midazolam 0. 015 mg/kg or NS （the same ml. as midazolam）. Myoclonus were observed and recorded. Both groups received fentanyl 4 μg/kg,and roeuronium 0.6mg/kg 1 min later; tracheal intubation was performed after muscle relaxant completely. Results Only 5 patients in group midazolam were found myoclonus slightly,39 patients in control group （P 〈0.01）. There was no significant difference between male and female in control group. Conclusions IThe effect of pretreatment of midazolam（0. 015 mg/kg）can reduce myoclonus after etomidate induction of general anesthesia.