| 产新德里金属β-内酰胺酶型细菌的研究进展 |
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| 引用本文： | 王凤霞,胡志东. 产新德里金属β-内酰胺酶型细菌的研究进展[J]. 国际流行病学传染病学杂志, 2010, 38(6): 128-130. DOI: 10.3760/cma.j.issn.1673-4149.2011.02.015 |
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| 作者姓名： | 王凤霞 胡志东 |
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| 作者单位： | 天津医科大学总医院微生物与免疫检验科,300052; |
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| 摘 要： | 新德里金属β-内酰胺酶(NDM-1)是近来发现的由新的超级耐药基因编码的一种耐药酶.编码该酶的基冈位于质粒等町移动遗传因子上,使得该类酶基因可在细菌间广泛传播.产此类酶的细菌对几乎所有现存的抗生素耐药.此文就NDM-1的流行病学特征、分子生物学特性和耐药机制等作了综述.
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| 关 键 词： | β-内酰胺酶类 质粒 肠杆菌科 肺炎克雷伯菌 |
Research advances in bacteria with New Delhi metallo-beta-lactamase |
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| WANG Feng-xia,HU Zhi-dong. Research advances in bacteria with New Delhi metallo-beta-lactamase[J]. International Journal of Epidemiology and Infectious Disease, 2010, 38(6): 128-130. DOI: 10.3760/cma.j.issn.1673-4149.2011.02.015 |
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| Authors: | WANG Feng-xia HU Zhi-dong |
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| Abstract: | New Delhi metallo-beta-lactamase (NDM-1) is a novel drug-resistant enzyme, which is encoded by a new super drug-resistant gene. The NDM-1 encoding gene is located on mobile genes such as plasmid, which can widely spread through bacterial populations. Moreover, bacteria with NDM-1 are resistant to almost all the antibiotics. This review is mainly about the epidemiological study, molecular biological properties and drug-resistant mechanism of NDM-1. |
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| Keywords: | Beta-lactamasePlasmidEnterobacteriaceaeKlebsiella pneumoniae |
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