Hepatocyte growth factor suppresses tumor cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 protein expression |
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| Authors: | Bian Li-juan Liao Bing Li Zhi Li Yang Liang Ying-jie |
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| Affiliation: | 1. Department of Pathology, 1st Affiliated Hospital, Sun Yat-sen University, 58#, Zhongshan Road II, Guangzhou 510080, China;2. Department of Pathology, 2nd Affiliated Hospital, Sun Yat-sen University, 107#, Yanjiangxi Road, Guangzhou 510120, China |
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| Abstract: | Hepatocyte growth factor (HGF) is a multifunctional cytokine, but cell apoptosis related to HGF in nasopharyngeal carcinoma (NPC) and the potential mechanisms involved have not yet been identified. In this study, we aimed at determining whether HGF is a potent inhibitor of cell apoptosis in NPC, and tried to find out which antiapoptotic or proapoptotic protein is involved in this process. |
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| Keywords: | Nasopharyngeal carcinoma (NPC) Hepatocyte growth factor (HGF) Apoptosis Antiapoptotic Bcl-2 protein |
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