器官移植病人HHV—6和HCMV感染的追踪研究

用病毒分离,ＰＣＲ和血清学方法追踪研究３１例器官移植病人ＨＣＭＶ和ＨＨＶ－６感染情况及其对移植的影响。结果显示：ＨＣＭＶ和ＨＨＶ－６分离率分别为３５。．５％和４５．２％。术后ＤＮＡ阳性率分别为２５．８％和３２．３％,术前相应的ＩｇＭ阳性率为０％和３．２％,术后ＩｇＭ阳性率分别为１９．４％和２５．８％;术前ＤＮＡ阳性率分别为３５．５％和４５．２％。术后ＤＮＡ阳性率分别高达４５．２％和６１．３％,并在

Follow-up study of human herpesvirus 6 and human cytomegalovirus infection in organ transplantation recipients]

OBJECTIVE: To trace the study of the prevalence and adverse factors of human herpesvirus 6(HHV-6) and human cytomegalovirus(HCMV) infection in organ transplantation recipients. METHOD: Blood and urine specimens were detected by virus isolation, polymerase chain reaction(PCR), and indirect immunofluorescent assay. RESULT: HCMV and HHV-6 isolation rate were 25.8% and 32.3%, respectively. Anti-HCMV IgM and anti-HHV-6 IgM positive rates before operation were 0% and 3.2%, their positive rates after operation were 19.4% and 25.8%, respectively. HCMV-DNA and HHV-6-DNA positive rates before operation were 35.5% and 45.2%; their positive rates after operation were 45.2% and 61.3%, and kept the high positive rates for a long period. The patients who died within 3 months were all complicated by HCMV and/or HHV-6 productive infection. The productive infection rates of HCMV and HHV-6 were 25.8% and 32.2%, respectively. CONCLUSION: The majority of HCMV and HHV-6 infection are reactivation. Productive infection attack at 2 weeks after operation, reaches the peak at 3-4 weeks after operation, and attacks at anytime within 3 months. HCMV and/or HHV-6 productive infection are fatal to recipients.