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| 福建汉族人群HLA-DRB1等位基因多态性研究 | |
| 引用本文： | 王庆华,陈威震,谭建明. 福建汉族人群HLA-DRB1等位基因多态性研究[J]. 中华医学遗传学杂志, 2006, 23(2) |
| 作者姓名： | 王庆华 陈威震 谭建明 |
| 作者单位： | 350025,福州,南京军区福州总医院器官移植研究所实验室 |
| 基金项目： | 全军“十五”课题-医学杰出人才基金(01J003)，上海市科委重大课题(024919005)~~ |
| 摘 要： | 目的调查福建汉族人群HLA-DRB1等位基因的多态性。方法应用寡核苷酸基因芯片分型技术对福建地区620名汉族人群进行HLA-DRB1位点的基因分型。结果在HLA-DRB1位点共检出了14种等位基因,基因频率较高的依次为DRB1*09、12、15、04、08。结论福建汉族HLA-DRB1等位基因多态性与南方汉族人群相近,但也有其独特的特点。 |
| 关 键 词： | 人类白细胞抗原 遗传多态性基因分型 |
Analysis of HLA-DRB1 allele polymorphism in the Fujian Han nationality population of China |
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| WANG Qing-hua,CHEN Wei-zhen,TAN Jian-ming. Analysis of HLA-DRB1 allele polymorphism in the Fujian Han nationality population of China[J]. Chinese journal of medical genetics, 2006, 23(2) | |
| Authors: | WANG Qing-hua CHEN Wei-zhen TAN Jian-ming |
| Abstract: | Objective To investigate the HLA-DRB1 allele polymorphism in Fujian Han nationality population. Methods Six hundred and twenty individual samples collected from unrelated Fujian Han population were subjected to genotyping using oligonucleotide microarray technique. And the allele frequencies of HLA-DRB1 were calculated and compared with other populations. Results Fourteen HLA-DRB1 alleles of Fujian Han population were detected. The gene frequencies ordered from high to low were HLA-DRB1*9, 12, 15, 4, 8 respectively. Conclusion The HLA-DRB1 distribution of Fujian Han population shares some genetic characters with southern Chinese Han populations, but these characters differ from northern Chinese populations. |
| Keywords: | human leukocyte antigen genetic polymorphism genotyping |
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