影响糖尿病患者肾小球滤过率危险因素的分析

为探讨各种危险因素对糖尿病患者肾小球滤过率 (GFR)的影响 ,应用多元逐步回归方法对 2 1 4例 2型糖尿病患者有关GFR的危险因素进行分析。结果 :①GFR下降组的年龄、病程、高血压史、冠心病史、视网膜病变患病率、腰臀围比值均明显高于GFR正常组 (P <0 .0 1 )。② 2组的GFR、尿素氮、肌酐和尿白蛋白的对数值均有显著性差异 (P <0 .0 1 )。③多因素回归分析显示 :影响糖尿病病人GFR的主要因素依次为年龄、肌酐、视网膜病变、高血压史和尿素氮。提示 :为早期预防糖尿病肾病 ,除了要有效控制血糖外 ,还要严格控制血压和积极防治视网膜病变

Multiple Factor Analysis on Glomerul ar Filtration Rate in Type 2 Diabetes Mellitus

To evaluate the importance of different risk factors and their mutual interactions on glomerular filtration rat(GFR)in type 2 diabetes mellitus, an investigation was carried out on the relationship between GFR and various risk factors in 214 cases of type 2 diabetes by way of stepwise regression analysis method. Results: ① The average age, DM course, waist/hip-ratio, hypertension prevalence, coronary heart disease prevalence and diabetic retinopathy prevalence were higher in GFR dropped group than that of GFR normal group(P<0.01). ② The values of GFR, BUN, Scr, UAER were significant difference between two groups(P<0.01). ③ Multiple backward regression analysis showed that age, Scr, diabetic retinopathy, hypertension and BUN were independent risk factors for GFR. Conclusion: To dealy the decrease of GFR and prevent the occurrence of diabetic nephropathy, it is important not only to control blood sugar, but also to control blood pressure and relieve diabetic retinopathy.