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| 膀胱癌患者细胞色素氧化酶P450 2C19基因多态性分析 | |
| 引用本文： | 邢东亮,宋东奎,张莉蓉. 膀胱癌患者细胞色素氧化酶P450 2C19基因多态性分析[J]. 郑州大学学报(医学版), 2006, 41(2): 285-287 |
| 作者姓名： | 邢东亮 宋东奎 张莉蓉 |
| 作者单位： | 郑州大学第一附属医院泌尿外科,郑州,450052;郑州大学基础医学院临床药理学教研室,郑州,450052 |
| 基金项目： | 河南省医学科技人才创新工程项目 |
| 摘 要： | 目的:探讨膀胱癌患者细胞色素氧化酶P450 2C19(CYP2C19)基因多态性.方法:采用PCR-RFLP基因分析技术,对108例膀胱癌患者和112例非肿瘤同期住院对照患者CYP2C19基因2个常见突变位点m1和m2的多态性进行检测,并分析其与膀胱癌易感性的关系.结果:与对照组相比,膀胱癌组中强代谢型(EMs)频率高于弱代谢型(PMs)(x2=4.508,P＜0.05).吸烟、职业暴露、嗜食肉食为膀胱癌发病的危险因素.CYP2C19 EMs与吸烟、职业暴露和嗜食肉食3个环境因素存在基因-环境交互作用,影响膀胱癌的发病.结论:CYP2C19 EMs基因型与膀胱癌易感性有关. |
| 关 键 词： | CYP2C19 基因多态性 膀胱癌 |
| 收稿时间： | 2005-08-31 |
| 修稿时间： | 2005-08-31 |
Polymorphism of CYP2C19 gene in patients with bladder cancer |
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| XING Dongliang,SONG Dongkui,ZHANG Lirong. Polymorphism of CYP2C19 gene in patients with bladder cancer[J]. Journal of Zhengzhou University: Med Sci, 2006, 41(2): 285-287 | |
| Authors: | XING Dongliang SONG Dongkui ZHANG Lirong |
| Affiliation: | 1.Department of Urology, the First Affiliated Hospital, Zhengzhou University,Zhengzhou 450052; 2. Department of Clinical Pharmacology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052 |
| Abstract: | Aim: To investigate the genetic polymorphism of CYP2C19 in patients with bladder cancer (BC).Methods: A total of 108 cases and 112 controls were enrolled to detect the CYP2C19 genotyping at two major polymorphic loci of gene coding area: CYP2C19m1 and CYP2C19m2 using PCR-RFLP method.Results: Compared with control, the percentage of EMs in BC group was higher than that of PMs (P<0.05).Smoking, occupational exposure and addicted to meat consumption were risk factors to BC.The gene-environment interaction between CYP2C19 EMs and smoking, occupational exposure and addicted to meat consumption could increase the risk of BC significantly.Conclusion: There is association between polymorphism of CYP2C19 EMs gene and BC risk. |
| Keywords: | CYP2C19 gene genetic polymorphism Madder cancer |
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