二烯丙基二硫通过细胞外信号调节激酶途径调节HepG2细胞Survivin表达 |
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引用本文: | 虞佳,殷杰,刘丽娟,向琼,雷小勇.二烯丙基二硫通过细胞外信号调节激酶途径调节HepG2细胞Survivin表达[J].南华大学学报(医学版),2009,37(6):639-642. |
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作者姓名: | 虞佳 殷杰 刘丽娟 向琼 雷小勇 |
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作者单位: | 南华大学,药物药理研究所,湖南,衡阳,421001 |
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基金项目: | 湖南省教育厅资助科研项目 |
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摘 要: | 目的探讨二烯丙基二硫(DADS)对HepG2细胞增殖的影响及其机制。方法W estern b lot法检测survivin、细胞外信号调节激酶(ERK1/2)和p-ERK1/2的表达;AO/EB染色观察细胞形态学变化。结果ERK1/2抑制剂PD98059抑制DADS诱导survivin表达的作用。PD98059与DADS联合应用可以促进HepG2细胞凋亡。结论DADS诱导HepG2细胞survivin的表达与ERK1/2信号通路有关。
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关 键 词: | 二烯丙基二硫 HepG2细胞 Survivin 细胞外信号调节激酶1/2 |
Regulation of Survivin Expression by Diallyl Disulfide and ERK Pathway in HepG2 Cells |
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Institution: | YU Jia, YIN Jie, LIU Li - juan, et al (Institute of Pharmacy and Pharmacology, University of South Nanhua , Hengyang , Hunan 421001, China ) |
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Abstract: | Objective To investigate the effect and the mechanism of of HepG2 cells proliferation by diallyl disulfide ( DADS ). Methods The proteins expression of extracellular signal - regulated kinase ( ERK1/2 ), p - ERK1/2 and survivin was detected by western - blot. Morphological assessment of apoptosis was by acridine orange ( AO ) and ethidium bromide ( EB ) fluorescence double staining. Results An ERK1/2 inhibitor PD98059 diminished the expression of survivin which was induced by DADS. PD98059 combining with DADS resulted in HepG2 cells apoptosis. Conclusions The ERK signaling pathway was involved in DADS -induced survivin expression. |
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Keywords: | Survivin |
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