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| 吉非罗齐预治疗对兔缺血再灌注心肌的保护作用 | |
| 引用本文： | 韦兵,吴洁. 吉非罗齐预治疗对兔缺血再灌注心肌的保护作用[J]. 南华大学学报(医学版), 2008, 36(5) |
| 作者姓名： | 韦兵 吴洁 |
| 作者单位： | 1. 南华大学,第一附属医院,胸心外科,湖南,衡阳,421001 2. 南华大学,第一附属医院,心内科 |
| 基金项目： | 湖南省卫生厅科研项目 |
| 摘 要： | 目的 探讨吉非罗齐预治疗对高脂血症兔心肌缺血再灌注损伤的影响.方法 采用冠状动脉左前降支结扎法复制家兔心肌缺血再灌注损伤模型.24只新西兰大白兔随机分3组,每组8只.缺血再灌注(I/R)组:缺血再灌注前12周予以高脂饲料(1%胆固醇、7.5%蛋黄粉和8%猪油)饲养;吉非罗齐组:缺血再灌注前高脂饮食饲养8周,在继续饲以高脂饲料的基础上给予吉非罗齐(200mg/kg·d)口服4周;假手术组:高脂饲料饲养12周后,仅在左前降支下穿线,并不结扎.观察各组不同实验阶段血浆肿瘤坏死因子-α(TNF-α)水平的变化,以及心肌细胞超微结构的变化并测定心肌梗死面积.结果 吉非罗齐组心肌缺血及再灌注后血浆TNF-α水平显著低于I/R组(P<0.01);吉非罗齐组心肌细胞超微结构破坏及心肌梗死面积均明显小于I/R组.结论 吉非罗齐预治疗可减轻高脂血症兔心肌缺血再灌注损伤. |
| 关 键 词： | 动脉粥样硬化 缺血-再灌注损伤 吉非罗齐 心肌保护 肿瘤坏死因子-α |
Myocardial Protective Effects of Pretreatment With Gemfibrozil on Ischemia/Reperfusion Myocardium in Rabbits |
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| WEI Bing,WU Jie. Myocardial Protective Effects of Pretreatment With Gemfibrozil on Ischemia/Reperfusion Myocardium in Rabbits[J]. Journal of Nanhua University(Medical Edition), 2008, 36(5) | |
| Authors: | WEI Bing WU Jie |
| Affiliation: | WEI Bing,WU Jie (Department of Cardiothoracic Surgery,the First Affiliated Hospital of Nanhua University,Hengyang,Hunan 421001,China) |
| Abstract: | Objective To investigate the effect of pretreatment with gemfibrozil on myocardium ischemia/reperfusion injury in atherosclerotic rabbits. Methods Myocardial ischemia/reperfusion models were built through ligating the left anterior descending(LAD) of New Zealand rabbits in vivo.Twenty-four New Zealand white rabbits were randomly divided into three groups: the ischemia/reperfusion(I/R) group,the ischemia/reperfusion with gemfibrozil treatment group,and the sham group.The serum TNF-alpha levels were measured ... |
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