糖尿病胰岛移植及细胞治疗的细胞来源

胰岛移植或细胞治疗是根治1型糖尿病较为理想的方法,但同时也面临着供体匮乏的难题。近年来研究显示,除同种自体或异体胰岛外,异种胰岛尤其是选择猪供胰成为众多学者关注的焦点;另外对扩增胰腺β细胞及制造胰岛素分泌细胞株的研究亦取得了一定的成果;而干细胞工程及转基因技术的应用,使利用干细胞治疗糖尿病及人工构建类胰岛细胞成为可能。

Relationship between leptin and nonalcoholic fatty liver disease

Leptin is an adipocytokine produced primarily in white adipose tissue. It belongs to pro-teohormone and plays biological effect by binding with leptin receptor. It is found that leptin regulates the me-tabolism of body and controlls the fatty mass. Recently studies have indicated that it is closely related to non-alcoholic fatty liver disease (NAFLD), but the results varied in different researches. Some found that there was no significant relation between higher level of leptin and NAFLD. On the contrary, others considered that leptin had indenpendent and very important role in the pathogenesis of NAFLD. The weakeness of leptin's an-tilipotoxicity and leptin resistance are considered as very important links in the pathogenesis of NAFLD.