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| 中药配伍减毒研究的新思路 | |
| 引用本文： | 李彦文,李志勇,刘会永,谭鹏,杨策,赵英凯,崔蒙.中药配伍减毒研究的新思路[J].中国实验方剂学杂志,2012,18(20):321-324. |
| 作者姓名： | 李彦文 李志勇 刘会永 谭鹏 杨策 赵英凯 崔蒙 |
| 作者单位： | 1. 中国中医科学院中医药信息研究所,北京,100700 2. 中央民族大学中国少数民族传统医学研究院,北京,100081 3. 北京邮电大学网络与交换技术国家重点实验室,北京,100876 4. 北京中医药大学中药学院,北京,100102 |
| 基金项目： | 科技部重大新药创制项目(2009ZX09301-005-01);国家自然科学基金青年基金项目(81001693,81102807) |
| 摘 要： | 中药配伍减毒涉及的复杂反应过程制约了对配伍减毒机制的深层次解构。阐明配伍减毒机制是解决中药毒性问题的关键。"效毒二重性"决定了有毒中药"效-毒交集"特征,交集调控可反映配伍减毒复杂过程。网络药理学的出现,为开展有毒中药毒性成分筛查、致毒机制和减毒效应等研究提供了新的手段。在回顾中药毒性研究实践的基础上,系统阐述网络药理学在中药配伍减毒研究中的应用策略,并以附子为例探讨其可行性。 |
| 关 键 词： | 中药配伍 减毒 网络药理学 |
| 收稿时间： | 5/9/2012 12:00:00 AM |
New Thought of Traditional Chinese Medicine in Detoxification by Compatibility |
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| LI Yan-wen,LI Zhi-yong,LIU Hui-yong,TAN Peng,YANG Ce,ZHAO Ying-kai and CUI Meng.New Thought of Traditional Chinese Medicine in Detoxification by Compatibility[J].China Journal of Experimental Traditional Medical Formulae,2012,18(20):321-324. | |
| Authors: | LI Yan-wen LI Zhi-yong LIU Hui-yong TAN Peng YANG Ce ZHAO Ying-kai and CUI Meng |
| Institution: | Institute of Information on Traditional Chinese Medicine of China Academy of Chinese Medical Sciences, Beijing 100700, China;China Minority Traditional Medical Center of Minzu University of China, Beijing 100081, China;State Key Laboratory of Networking and Switching of Beijing University of Posts and Telecommunications, Beijing 100876, China;School of Chinese Pharmacy of Beijing University of Chinese Medicine, Beijing 100102, China;Institute of Information on Traditional Chinese Medicine of China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Information on Traditional Chinese Medicine of China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Information on Traditional Chinese Medicine of China Academy of Chinese Medical Sciences, Beijing 100700, China |
| Abstract: | |
| Keywords: | compatibility of traditional Chinese medicnie detoxification network pharmacology |
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