延黄妇炎清片对慢性盆腔炎大鼠血清中SOD、MDA影响的实验研究

目的:探讨延黄妇炎清片治疗慢性盆腔炎的作用机制。方法:采用苯酚胶浆法制成大鼠慢性盆腔炎模型。随机将50只SD大鼠分为5组,即假手术组、模型对照组、阳性对照组(金鸡片)、延黄妇炎清片小剂量组、延黄妇炎清片大剂量组。连续灌胃服药1月后,检测大鼠血清中超氧化物歧化酶(SOD)、丙二醛(MDA)的含量。结果:与模型组比较,假手术组、延黄妇炎清片大、小剂量组及金鸡片组大鼠血清SOD水平明显增高,MDA含量明显降低,差异均有显著性或非常显著性意义(P0.01,P0.05)。结论:延黄妇炎清片通过影响SOD、MDA的含量而达到对慢性盆腔炎的治疗作用。

Experiment Research of Yanhuang Fuyanqing Tablets in Influencing Serum SOD and MDA in Model Rats of Chronic Pelvic Inflammatory Disease

Objective： To study the mechanism of Yanhuang Fuyanqing tablets for the treatment of chronic pelvic inflammatory disease. Methods： Chronic pelvic inflammation rat model was established by phenol mucilage method. Fifty model rats were randomly divided into 5 groups： sham operation（SO）group, model control（MC） group, positive control（PC） group, high-dose Yanhuang Fuyaning tablets（YFT） group, and low-dose YFT group. Serum super oxide dismutase（SOD） and malondialdehyde（MDA） contents were detected after gastric gavage for continuous one month. Results： The content of SOD was obviously higher and MOD content was significantly lower in SO, PC, high-dose YFT and low-dose YFT groups than that in MC group （P 〈 0.01, P 〈0.05）. Conclusion： Yanhuang Fuyanqing tablets have curative effect for chronic pelvic inflammatory disease by regulating the contents of SOD and MDA.