不同分型慢性鼻-鼻窦炎患者外周血嗜酸性粒细胞与中性粒细胞百分比及变态反应临床差异性分析

目的 分析不同分型慢性鼻-鼻窦炎(CRS)患者外周血嗜酸性粒细胞与中性粒细胞百分比及变态反应临床差异性。 方法 前瞻性选取2015年5月至2017年5月间在上海市宝山区大场医院和上海中医药大学附属曙光医院宝山分院接受治疗的150例CRS患者,收集患者临床资料,皮肤点刺试验的结果及外周血内中性粒细胞和嗜酸性粒细胞所占比率,分析其与CRS起病联系情况。 结果 150例患者手术后病理诊断显示45例为中性粒细胞型,105例为嗜酸性粒细胞型;嗜酸性粒细胞的浸润型患者外周血内嗜酸性粒细胞所占比率高于中性粒细胞的浸润型患者,差异有统计学意义(P<0.05);慢性鼻-鼻窦炎不伴鼻息肉(CRSsNP)、慢性鼻-鼻窦炎伴息肉(CRSwNP)分型和免疫病理的分型在两种不同浸润型患者内分布对比差异无统计学意义(P>0.05)。 结论 CRS病理组织内中性粒细胞和嗜酸性粒细胞的浸润程度与其外周血内嗜酸性粒细胞所占比率有关,局部嗜酸性粒细胞和外周血内嗜酸性粒细胞的浸润程度呈现为一致性。

Clinical significance of eosinophils and neutrophils in blood and allergic reaction in patients with chronic rhinosinusitis

Objective To analyze the percentage of eosinophils and neutrophils in the blood of patients with chronic rhinosinusitis(CRS)and clinical differences in allergic reactions. Methods We prospectively selected 150 patients with CRS treated in Baoshan District Dacheng Hospital in Shanghai and Dawn Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from May 2015 to May 2017. Clinical data and skin prick test results were collected, and the ratio of neutrophils and eosinophils in the blood, and their association with the onset of CRS, were analyzed. Results The pathological diagnosis showed that 45 cases were neutrophilic and 105 cases were eosinophilic. The percentage of eosinophilic granulocytes in the blood of patients with infiltrating eosinophils was significantly higher than that in the blood of patients with infiltrating neutrophils(P < 0.05). There were no significant differences in the distribution of CRS without nasal polyps, CRS with nasal polyps, and immunopathological features between the two groups of infiltrated patients(P>0.05). Conclusion The degree of infiltration of neutrophils and eosinophils in the pathological tissues of CRS patients was related to the ratio of eosinophils in the blood, and the degree of infiltration of local eosinophils and peripheral blood eosinophils appeared to be consistent.