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Anti-tumor angiogenesis with a recombinant ag43/FGFR1 chimeric protein as a model antigen |
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| Authors: | Shaoping Zheng Zhihong Weng Shaojiang Zheng Junli Guo Fengying Huang Mingxing Xie |
| Affiliation: | 1. Department of Ultrasonography,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wu-han 430022,China;Department of Pathology and Hainan Provincial Key Laboratory of Tr 2. Department of Ultrasonography,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wu-han 430022,China 3. Department of Pathology and Hainan Provincial Key Laboratory of Tropical Medicine,Hainan Medical College,Haikou 571101,China |
| Abstract: | In order to investigate the anti-tumor angiogenesis activity with a recombinant Ag43/FGFR1 chimeric protein(AF)vaccine in a mouse H22 hepatoma model,tumor volume and survival rate of the mice were studied at a 3-day interval.Microvessel density(MVD)was detected by immunohistochemistry.The endothelial deposition of autoantibodies within tumor tissues was examined by immunofluorescent staining,and anti-FGFR1 antibody-producing B cells(APBCs)were tested by enzyme-linked immunospot(ELISPOT)assay.Compared with t... |
| Keywords: | fibroblast growth factor receptor-1 antigen 43 angiogenesis immunotherapy |
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