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| 冠心病患者循环内皮祖细胞与血浆非对称二甲基精氨酸的相关分析 | |
| 引用本文： | 余华,张怀勤,杜晓红,肖方毅,黄伟剑,林捷. 冠心病患者循环内皮祖细胞与血浆非对称二甲基精氨酸的相关分析[J]. 中华老年心脑血管病杂志, 2008, 10(9): 668-670 |
| 作者姓名： | 余华 张怀勤 杜晓红 肖方毅 黄伟剑 林捷 |
| 作者单位： | 温州医学院附属第一医院,温州,32500 |
| 摘 要： | 目的探讨冠心病患者循环内皮祖细胞(EPCs)水平与血浆非对称二甲基精氨酸(ADMA)浓度的相关性及临床意义。方法将确诊或疑似冠心病的87例患者分为2组,经冠状动脉造影证实冠心病的患者55例为冠心病组,造影证实非冠心病患者32例为非冠心病组,采用流式细胞技术分析外周血循环EPCs水平,高效液相色谱分析法检测血浆ADMA浓度。结果冠心病组患者EPCs(0.033±0.014)%较非冠心病组(0.054±0.013)%显著降低,冠心病组患者血浆ADMA(0.374±0.059)mg/L较非冠心病组(0.317±0.023)mg/L显著升高(P<0.01);冠心病组循环EPCs水平与血浆ADMA浓度呈负相关(r=-0.691,P<0.01)。结论冠心病患者高浓度的血浆ADMA可能是外周血循环EPCs水平降低的原因之一。 |
| 关 键 词： | 冠状动脉疾病 内皮细胞 流式细胞术 色谱法,高压液相 非对称二甲基精氨酸 |
The relationship between circulating endothelial progenitor cells and plasma asymmetric dimethylarginine in coronary artery disease |
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| YU Hua,ZHANG Huai-qin,DU Xiao-hong,et al. The relationship between circulating endothelial progenitor cells and plasma asymmetric dimethylarginine in coronary artery disease[J]. Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Diseases, 2008, 10(9): 668-670 | |
| Authors: | YU Hua ZHANG Huai-qin DU Xiao-hong et al |
| Affiliation: | YU Hua,ZHANG Huai-qin,DU Xiao-hong,et al(Department of Medical Care for Cadres,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China) |
| Abstract: | Objective To study The relationship between circulating endothelial progenitor cells(EPCs)and plasma asymmetric dimethylarginine(ADMA)in patients with coronary artery disease.Methods Eighty-seven patients were divided into 2 groups according to the diagnosis by coronary arteriography:55 cases of coronary artery disease and 32 cases of non-coronary artery disease.Circulating EPCs level was determined by FACS assay and plasma concentration of ADMA was analyzed by high performance liquid chromatography(HPLC).R... |
| Keywords: | coronary disease endothelial cells flow cytometry chromatography high pressure liquid asymmetric dimethylarginine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |