131I治疗甲亢患者疗效观察及其对外周血液的影响

目的探讨131I治疗甲亢患者疗效观察,对外周血液的影响及其临床意义.方法采用ACCESS微粒子化学发光免疫分析检测了210例甲亢患者131I治疗前、后和110例对照组血清中T3、T4、TSH;COULTER三分类血细胞分析测定Hb、RBC、WBC&DC及Plt含量.结果应用131I治疗甲亢患者疗效显著(P＜0.001).治疗前、后外周血液(Hb、MCV、MCH、MCHC、RDW、Hct、WBC、LY、Plt、MPV、Pct、PDW)与对照组比较均有显著性差异(P＜0.001),而治疗前、后比较无显著性差异(P＞0.05).结论应用131I治疗甲亢患者疗效显著,治疗剂量核素辐射对外周血液不会受到明显影响.

Effect of Successful 131I Treatment on the Peripheral Blood Picture in Hyperthyroid Patients

Objective To investigate the effect of successful 131 I therapy on the levels peripheral blood picture in hyperthyroid patients. Methods Serum T 3, T 4, TSH (with ACCESS microparticle chemiluminesccence immuoassay) and blood Hb, RBC, WBC&DC, Plt (with COULTER three assortments) counts were determined in 110 controls and 210 hyperthyroid patients both before and after 131 I therapy. Results 131 I treatment of hyperthyroidism in this group of patients was very successful (P<0.001). Peripheral blood picture (Hb, MCV, MCH, MCHC, RDW, Hct, WBC, LY, Plt, MPV, Pct, PDW) readings in the hyperthyroid patients were significantly different from those in controls both before and after treatment (P<0.001). However, in the patients there were few changes of the readings after 131 I therapy. Conclusion The application of 131 I to treat hyperthryoidism was very successful with no remarkable effect on peripheral blood picture.