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| 硒蛋白对氧化还原信号的调控作用 | |
| 引用本文： | 李春燕,曹春霞. 硒蛋白对氧化还原信号的调控作用[J]. 国外医学:医学地理分册, 2011, 32(2): 143-147. DOI: 10.3969/j.issn.1001-8883.2011.02.022 |
| 作者姓名： | 李春燕 曹春霞 |
| 作者单位： | 1. 西安交通大学医学院公卫系,陕西西安,710061 2. 武警医学院部队健康教育教研室,天津,300162 |
| 基金项目： | 国家自然科学基金资助项目，陕西省13115创新专项 |
| 摘 要： | 在生命过程中,机体通过特定的机制抑制以ROS为传感器和信号的还原氧造成的氧化损伤.Cys和Met的氧化修饰对蛋白质活性、结构、稳定性及亚细胞的定位均有深远影响.硒是人体不可缺少的微量元素,是红细胞抗氧化剂- GSH-Px的重要成份,充足的硒可使GSH-Px有效地将H2O2转变为水.硒的大部分生物活性取决于硒蛋白的Sec... |
| 关 键 词： | 硒 硒蛋白 氧化还原 信号 |
Regulatory role of selenoprotein on the redox signaling |
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| LI Chun-yan,CAO Chun-xia. Regulatory role of selenoprotein on the redox signaling[J]. Foreign Medical Sciences(Section of Medgeography), 2011, 32(2): 143-147. DOI: 10.3969/j.issn.1001-8883.2011.02.022 | |
| Authors: | LI Chun-yan CAO Chun-xia |
| Affiliation: | LI Chun-yan , CAO Chun-xia , GUO Xiong (1. Department of Public Health, School of Medicine, Xi＇an Jiaotong University, Xi＇an 7100611 ;Department of Military Health Education, Medical School of Armed Police, Tianjing 300162, China) |
| Abstract: | Selenium is an important trace element in body function. It is erythrocyte antioxidant and vital composition of GSH-Px. Adequate selenium can make GSH-Px turn H2 O2 into water. Selenoprotein is rich in GSH- Px, which can eliminate H2 O2 and lipid H2 O2, and inhibit the intensity and duration of ROS signaling. The biology activity of several selenoproteins in the endoplasmic reticulum has not been decided so far, but it＇s known that they are involved in the formation of protein bisulfide, and the regulation of responsive signaling of unfolded protein. Recent studies have indicated that selenoprotein W and thioredoxin selenoprotein can help to transmit signals to disulfide linkage regulated by target protein. |
| Keywords: | selenium selenoprotein redox signal |
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