| 乙型肝炎患者肝组织CD8+T淋巴细胞CD28的表达及临床意义 |
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| 引用本文： | 荣梅生,明丽娟,耿建,沈继龙.乙型肝炎患者肝组织CD8+T淋巴细胞CD28的表达及临床意义[J].蚌埠医学院学报,2010,35(12):1293-1295. |
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| 作者姓名： | 荣梅生 明丽娟 耿建 沈继龙 |
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| 作者单位： | 安徽医科大学,寄生虫学教研室,安徽,合肥230031;蚌埠医学院,医学检验系,安徽,蚌埠,233030;蚌埠医学院,医学检验系,安徽,蚌埠,233030;安徽医科大学,寄生虫学教研室,安徽,合肥230031 |
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| 摘 要： | 目的：探讨乙型肝炎患者肝组织CD8＋T淋巴细胞CD28的表达及其临床意义。方法：将100例乙型肝炎患者按照肝组织病理变化分为轻、中、重度,15名健康人肝组织为对照组,采用免疫组织化学双标记法检测肝组织CD8＋CD28＋T细胞和CD8＋CD28-T细胞。结果：乙型肝炎患者肝组织CD8＋CD28＋T细胞和CD8＋CD28-T细胞水平明显高于对照组（P〈0.05）。轻度乙型肝炎患者肝组织内CD8＋CD28＋T细胞水平较对照组低,乙型肝炎中度和重度患者CD8＋CD28＋T细胞和CD8＋CD28-T细胞明显高于对照组（P〈0.01）,且CD8＋CD28＋T细胞随着炎症分级逐级升高,CD8＋CD28-T细胞却随着炎症分级逐级减低。结论：肝组织内CD8＋T淋巴细胞表面CD28的表达强度与肝组织病变程度密切相关;肝组织内CD8＋CD28＋T细胞水平可作为判断乙型肝炎患者肝组织损伤的一个免疫学指标;肝组织内CD8＋CD28-T细胞可能是乙型肝炎持续感染的主要原因。
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| 关 键 词： | 乙型肝炎 肝组织 CD8 CD28 |
The clinical significance and the expression of CD28 on CD8+ T lymphocyte in liver tissue of hepatitis B patients |
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| RONG Mei-sheng,MING Li-juan,GENG Jian,SHEN Ji-long.The clinical significance and the expression of CD28 on CD8+ T lymphocyte in liver tissue of hepatitis B patients[J].Journal of Bengbu Medical College,2010,35(12):1293-1295. |
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| Authors: | RONG Mei-sheng MING Li-juan GENG Jian SHEN Ji-long |
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| Institution: | RONG Mei-sheng1,2,MING Li-juan2,GENG Jian2,SHEN Ji-long1(1.Department of Microbiology and Parasitology,Anhui Medical University,Hefei Anhui 230031,2.Department of Clinical Laboratory,Bengbu Medical College,Bengbu Anhui 233030,China) |
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| Abstract: | Objective:To study the expression and the clinical significance of CD28 on CD8+ T lymphocytes in liver tissue of hepatitis B patients.Methods:One hundred cases of hepatitis B patients were divided into mild,moderate and severe hepatitis B groups according to the pathological changes of liver tissues,and normal liver tissue of 15 healthy persons as the control group.CD8+CD28+ and CD8+CD28-T lymphocytes were determined in liver tissue with immunohistochemical double-labeling.Results:The CD8+CD28+ and CD8+CD28... |
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| Keywords: | hepatitis B liver tissue CD8 CD28 |
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