Maspin在肿瘤中表达水平与抑瘤特性关系的研究进展

Maspin（mammary serine protease inhibitor）基因是一种丝氨酸蛋白酶抑制剂（serpin）基因，其编码的蛋白对肿瘤具有多方面的抑制作用：抑制新生血管的生成、增加细胞间的黏附性、抑制肿瘤细胞的侵袭和转移能力、诱导肿瘤细胞凋亡。在一些肿瘤如乳腺癌、前列腺癌组织中，Maspin表达水平随肿瘤的发展逐渐降低，在另一些肿瘤如胰腺癌组织呈高表达。Maspin在不同组织中的表达情况及生物学功能，仍需进一步研究。

Tumor suppressive properties of maspin and its expression levels in tumors

Maspin (mammary serine protease inhibitor) is a kind of serpin.Many studies have characterized it as a tumor suppressor based on its ability to inhibit tumor angiogenesis,increase adhesion between tumor cells and ECM,inhibit tumor cell invasion and distant metastasis and promote apoptosis.In recent years,some studies have found maspin expresses high in some cancers,such as in mammary cancer and prostate cancer,while in some other cancers,such as in pancreatic cancer,maspin expression level shows high.The expression levels and biological functions of maspin in different organs still need further study.