培哚普利对急性冠状动脉综合征患者白介素-6和肿瘤坏死因子-α水平的影响

目的　观察急性冠状动脉综合征患者使用培哚普利治疗后白介素 - 6( IL- 6)和肿瘤坏死因子 ( TNF- α)水平的变化。方法　选择 10 0例诊断为不稳定型心绞痛 ( 73例 )和急性心肌梗死 ( 2 7例 )的病人分为两组 ,A组 ( 5 0例 )接受培哚普利治疗 2周 ,B组 ( 5 0例 )未接受培哚普利治疗。入院时和治疗 2周后分别检测 IL- 6和 TNF- α浓度。结果　入院时 A组 IL- 6和 TNF- α水平与 B组相比无显著性差异 ( 60 8.4± 112 .3 pg/ ml vs5 83 .1± 10 6.4pg/ m l,46.0±10 .4pg/ ml vs 44 .1± 8.8pg/ ml,P>0 .0 5 ) ,治疗两周后两组 IL - 6和 TNF-α水平均有降低 ,而 A组病人两周后 IL -6和 TNF- α水平与 B组相比有显著降低 ( 2 40 .5± 5 0 .4pg/ ml vs414.3± 98.6pg/ m l,16.2± 3 .5 pg/ m l vs3 2 .7± 6.2 pg/ ml,P<0 .0 5 )。结论　急性冠状动脉综合征患者应用培哚普利治疗后 IL - 6和 TNF-α水平降低 ,提示培哚普利可能有直接抗炎作用

Impact of Perindopril on tumor necrosis factor-alpha and interleukin-6 release in patients with acute coronary syndromes

Objective To investigate the effect of Perindopril on intereukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) concentrations after acute coronary syndromes. Methods One hundred patients undergoing acute coronary syndromes were recruited, of whom 50 patients were receiving Perindopril for two weeks. Plasma IL-6 and TNF-α were measured pretreatmently and again after two weeks. Results Baseline IL-6 and TNF-α concentrations were non-significantly among the patients(608.4±112.3pg/ml vs 583.1±106.4pg/ml , 46.0±10.4pg/ml vs 44.1±8.8pg/ml, P>0.05). After two weeks, the IL-6 and TNF-α concentrations with Perindopril were significantly depressed (240.5±50.4pg/ml vs 414.3±98.6pg/ml, 16.2±3.5pg/ml vs 32.7±6.2pg/ml, P<0.05).