五味豆汤改善T2DM胰岛素抵抗的临床研究

目的:探讨五味豆汤对2型糖尿病(T2DM)胰岛素抵抗的影响。方法:用酶法测定二甲双胍组和五味豆汤组各20例的空腹血糖(FPG)、OGTT2h血糖(2hPG)、糖化血红蛋白(HbA1c)、空腹血浆胰岛素(FINS)、血脂,计算HOMA-IR指数、中医症状积分的变化。结果:治疗后HOMA-IR明显下降(P0.05),二甲双胍组和五味豆汤组比较无显著性差异(P0.05)。治疗后FBG、FINS、Hb1Ac、2hPG、TC在二甲双胍组和五味豆汤组明显下降(P0.05),二甲双胍组和五味豆汤组比较无明显差异(P0.05)。治疗后中医症状积分在在二甲双胍组和五味豆汤组明显下降(P0.05),二甲双胍组和五味豆汤组进行组间比较有显著差异(P0.05)。结论:五味豆汤可以明显减轻胰岛素抵抗。

Clinical research of improving T2DM insulin resistance with the Wuweidou decoction

Objective:To investigate the impact of the Wuweidou decoction against insulin resistance of type 2 diabetes mellitus(T2DM).Methods:enzymatic measurement of fasting plasma glucose(FPG),OGTT2h glucose(2hPG),glycosylated hemoglobin(HbA1c),fasting plasma insulin(FINS) and lipids of two groups(metformin group and Wuweidou decoction group),TCM calculated HOMA-IR index and symptom score changes.Results:HOMA-IR decreased significantly after treatment(P<0.05),the two group showed no significant difference(P>0.05).FBG、FINS、Hb1Ac、2hPG、TC in the two groups decreased significantly(P<0.05),the two group showed no significant difference(P>0.05).TCM symptom score decreased significantly in the two groups(P<0.05),groups were compared,has a significant difference(P<0.05).Conclusion:The Wuweidou decoction could significantly reduce insulin resistance.