离体心肌磁共振波谱的实验研究

目的 连续观察离体心肌高能磷酸盐代谢和寻找其变化的规律；探讨＾３１Ｐ ＭＲ波谱的敏感性；观察离体心肌能量代谢与缺血时间的关系。方法 ８例健康犬离体前后心脏用于＾３１Ｐ ＭＲ波谱的动态观察。结果 心脏离体后，磷酸肌酸（ＰＣｒ）迅速下降。离体２￣３小时后，ＰＣｒ降至零水平。直到离体６小时，三磷酸腺苷（ＡＴＰ）水平逐渐耗竭。结论 在心脏离体后２￣３小时，心肌ＰＣｒ迅速下降到离体６小时，三磷酸腺苷（ＡＴＰ

Experimental study of 31 P MR spectroscopy in vitro canine myocardium

Objective To conduct a dynamic survey of the metabolism of highenergy phosphates in myocardium in order to define, the relationship between the changes in myocardial energy metabolism and the duration of ischemia. Methods A dynamic survey of isolated heart of 8 dogs was done with the use of31P MRS. Results Myocardial PCr level decreased rapidly after the heart was isolated and was reduced to zero in 2-3 hours. ATP level diminished progressively to its depletion at 6 hours following isolation. Conclusions After the heart was isolated, the PCr level rapidly decreased and was reduced to zero in 2-3 hours whereas ATP was not depleted until 4-6 hours after isolation. The ATP level remained within normal limits as long as PCr had not been depleted.