三倍量国产钆喷替酸葡甲胺增强MRI探查脑转移瘤的研究

目的 评价３倍量（０．３ｍｍｏｌ／ｇ）国产钆喷替酸葡甲胺（Ｇｄ－ＤＴＰＡ）增强ＭＲＩ探查脑转移瘤的效果。方法 用国产Ｇｄ－ＤＴＰＡ３倍量增加ＭＲＩ检查５５例怀疑脑转移瘤的患者。对ＭＲ扫描所见进行定性，定量分析。结果 ３倍量增强比常规量增强扫描发现了理多的转移病灶，分别为３７及１７５个。对３倍量增强扫描多发现的１３８个病灶的定量分析表明，３倍量增强使病灶的相对信号强度明显增高。尤其值得指出的是，２

Investigation on detection of brain metastases with triple dose China made Gd DTPA

Objective To assess the effectiveness of triple dose China made Gd DTPA in the MR evaluation of patients with brain metastases Methods 55 patients with clinical suspicion of brain metastases were studied prospectively with China made Gd DTPA MR findings were analyzed qualitatively and quantitatively Results 28 patients were proved to have metastases A significantly greater number of lesions was seen on triple dose as opposed to the standard dose images (37/175) Quantitative analysis of the 138 lesions demonstrated only in triple dose contrast images showed increase in relative signal intensity when compared with standard dose studies 2 patients with negative finding with standard dose had lesions identified on triple dose study 3 patients with solitary lesion on standard dose examination demonstrated multiple metastases on triple Conclusions Triple dose (0 3 mmol/kg) contrast study provides improved lesion detectability and additional diagnostic information over the study performed in the same patients with conventional dose (0 1 mmol/kg)