| 河南汉族人群细胞色素P-450 1A1与肺癌易感性的关系 |
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| 引用本文： | 李英,唐学义,马希涛. 河南汉族人群细胞色素P-450 1A1与肺癌易感性的关系[J]. 河南医学研究, 2005, 14(3): 227-229 |
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| 作者姓名： | 李英 唐学义 马希涛 |
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| 作者单位： | 河南省人民医院呼吸内科,河南,郑州,450003;河南省人民医院呼吸内科,河南,郑州,450003;河南省人民医院呼吸内科,河南,郑州,450003 |
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| 基金项目： | 2000年度国家杰出青年科学基金项目,编号:30025016。 |
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| 摘 要： | 目的:探讨CYP1A1基因多态与支气管肺癌癌变关系。方法:采用病例-对照设计和PCR-RFLP方法,检测肺癌组103例和对照组138例CYP1A1基因多态,以logistic回归模型计算比数比(odds ratios,OR)及95%可信区间(confidential intervals,CI)。结果:CYP1A1m1突变型等位基因频率在对照组和肺癌组分别为27.6%和42.7%。logistic回归分析表明,CYP1A1(w1/m1)杂合型(B型)和(m1/m1)纯合突变型(C型)患肺癌的危险度分别升高3.19和2.61倍,差异显著。结论:CYP1A m1突变型等位基因是患肺癌的危险因素。
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| 关 键 词： | 肺肿瘤 基因多态 遗传易感性 细胞色素P-450 1A1 |
| 文章编号： | 1004-437X(2005)03-0227-03 |
| 修稿时间： | 2005-05-18 |
Cytochrome P-450 1A1 polymorphisms and susceptibility to lung cancer: a case-control study on Chinese population in Henan |
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| LI Ying,TANG Xue-yi,MA Xi-tao. Cytochrome P-450 1A1 polymorphisms and susceptibility to lung cancer: a case-control study on Chinese population in Henan[J]. Henan Medical Research, 2005, 14(3): 227-229 |
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| Authors: | LI Ying TANG Xue-yi MA Xi-tao |
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| Abstract: | Objective: To study the relationship of CYP1A1 polymorphisms with occurrence of bronchic lung cancer.Methods: The case_control study and PCR_RFLP was conducted among 103 subjects and 138 healthy controls,and the genetic polymorphism of CYP1A1 were detected.Logistic regression analyses were used to assess the value of odds ratios (OR) and confidential intervals (CI). Results: For CYP1A1,the allele frequencies of m1 were 27.6% and 42.7% in control and LC groups,respectively.OR for the CYP1A1 (B) or (C) genotype indicated 3.19 and (2.61) fold increased risk for developing LC.The association were statistically significant.Conclusion: The mutant genotypes of the CYP1A1 m1 polymorphisms raised risk of LC in the population. |
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| Keywords: | lung cancer genetic polymorphism genetic susceptibility cytochrome P-450 1A1 |
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