乳腺癌耐药蛋白的表达及其与核转录因子snail相关性的临床研究

目的：探讨乳腺癌耐药蛋白（BCRP）的表达，分析其与核转录因子snail的相关性及BCRP介导肿瘤耐药的分子机制。方法：应用免疫组化方法检测87例乳腺癌组织和35例癌旁组织中BCRP和snail的表达情况，分析其与乳腺癌临床病理因素的关系及BCRP与snail的相关性。结果：BCRP和snail在乳腺癌组织中的阳性率分别32．18％和85．06％，BCRP与年龄、肿瘤大小及TNM分期无关，与组织学分级、ER表达和淋巴结转移相关；snail与患者年龄、肿瘤大小、组织学分级、ER表达无关，而与TMN分期、淋巴结璜移正相关；相关分析显示BCRP与snail表达的存在密切相关性（x^2=35267，P〈001，r=O643）。结论：BCRP参与了乳腺癌的进展；snail是乳腺癌上皮-间质转换（EMT）过程中的一个重要调节因素，促进了EMT的发生，介导了BCRP介导的多药耐药。

Study of expression of breast cancer resistance protein and its relationship with snail in breast cancer

Objective： To study the expression of breast cancer resistance protein, analyse the relationship between BCRP and snail and its molecular mechanism to drug resistance. Methods： The expression BCRP and snail in breast cancer and para-carcinoma tissue were detected with I- HC.The relationship between BCRP and snail clinicopathologic characteristics in breast cancer was analysed. Results： The positive rate of BCRP and snail in breast cancer tissue was 32.18% and 85.06% respectively. Expression of BCRP was not related to the patient age, tumor size, TNM stag- ing, but related to the histologic grade, ER expression and lymph node metastasis. Expression of snail was not related to the patient age, tumor size, histologic grade, ER expression ,