血管内皮生长因子在非小细胞肺癌中表达及意义

[目的]研究血管内皮生长因子(VEGF)在非小细胞肺癌(NSCLC)中的表达及意义.[方法]应用SABC免疫组化方法检测60例NSCLC中VEGF表达.[结果]NSCLC中VEGF阳性率为61.67%,明显高于癌旁正常组织(8.00%),P＜0.01.NSCLC中VEGF表达与临床分期及淋巴结转移显著相关.VEGF表达阴性组1、3、4年生存率分别为86.74%、64.05%、64.05%,而阳性组则分别为85.4%、43.64%、19.05%,经Log-Rank检验,差异有显著性(P＜0.05).[结论]VEGF在非小细胞肺癌血管形成及发展中起重要作用,并有助于预测肺癌患者的预后.

Expression of Vascular Endothelial Growth Factor in Patients with Non-small Cell Lung Cancer and Its Significance

[Purpose]To investigate the expression of vascular endothelial growth factor (VEGF) in patients with non-small cell lung cancer (NSCLC) and its significance.[Methods]The expression of VEGF was examined by immunohistochemistry in 60 cases of NSCLC.[Results]The positive rate of VEGF in NSCLC was 61.67%, it was significantly higher than that in normal lung tissues adjacent to carcinoma(8.00%),P<0.01.The VEGF positive expressions were correlated to clinical stage and lymph node metastases.The 1-,3-,4-year survival rates in patients with negative VEGF expression were 86.74%,64.05%,64.05% respectively.In contrast the 1-,3-,4-year survival rates in patients with positive VEGF expression were 85.4%,43.64%, 19.05% respectively. There was significant difference between two groups by Log-Rank analysis?(<0.05)?[Conclusion]VEGF plays an important role in the angiogenesis and development of NSCLC,and the detection of VEGF expression may be helpful to predict prognosis of NSCLC.