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| 阿魏酸衍生物的合成及抗血小板聚集活性 | |
| 引用本文： | Li JM,Zhao YH,Zhong GC,Long ZJ,Zhou P,Yuan M. 阿魏酸衍生物的合成及抗血小板聚集活性[J]. 药学学报, 2011, 46(3): 305-310 |
| 作者姓名： | Li JM Zhao YH Zhong GC Long ZJ Zhou P Yuan M |
| 作者单位： | 安徽中医学院药学院安徽省现代中药重点实验室; |
| 基金项目： | 国家“重大新药创制”科技重大专项资助项目(2009ZX09103-123); 安徽高校省级自然科学研究重点项目(KJ2010A206) |
| 摘 要： | 以具有活血化瘀作用的中药有效成分阿魏酸为先导物,设计合成了6个阿魏酸衍生物,其结构经IR、1H NMR、13C NMR及MS确证。体内药效筛选结果显示,阿魏酸衍生物对二磷酸腺苷(ADP)诱导的血小板聚集具有较好的抑制活性,其抑制作用明显强于阳性对照药奥扎格雷钠。 |
| 关 键 词： | 阿魏酸 阿魏酸衍生物 血栓 抗血小板聚集 |
Synthesis of ferulic acid derivatives and their inhibitory effect on platelet aggregation |
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| Li Jia-Ming,Zhao Yong-Hai,Zhong Guo-Chen,Long Zi-Jiang,Zhou Peng,Yuan Ming. Synthesis of ferulic acid derivatives and their inhibitory effect on platelet aggregation[J]. Acta pharmaceutica Sinica, 2011, 46(3): 305-310 | |
| Authors: | Li Jia-Ming Zhao Yong-Hai Zhong Guo-Chen Long Zi-Jiang Zhou Peng Yuan Ming |
| Affiliation: | LI Jia-ming,ZHAO Yong-hai,ZHONG Guo-chen,LONG Zi-jiang,ZHOU Peng,YUAN Ming(Anhui Key Laboratory of Traditional Chinese Medicine,School of Pharmacy,Anhui University of Traditional Chinese Medicine,Hefei 230031,China) |
| Abstract: | Ferulic acid,an useful compound of Chinese traditional medicine,was used as leading compound.Six ferulic acid derivatives were designed and synthesized based on bioisosterism.Their structures were characterized by IR,1H NMR,13C NMR and mass spectra.In vivo experiment showed that ferulic acid derivatives had good inhibitory effects on adenosine diphosphate(ADP) induced platelet aggregation,which were significantly higher than that of Ozagrel. |
| Keywords: | ferulic acid ferulic acid derivatives thrombosis platelet aggregation inhibition |
| 本文献已被 CNKI PubMed 等数据库收录！ | |