诺和锐30和诺和灵30R治疗新诊断2型糖尿病的临床比较

目的比较诺和锐30（BIAsp30）与诺和灵30R（BHI30）治疗新诊断2型糖尿病的临床疗效。方法 60例新诊断的2型糖尿病患者随机分为诺和锐30组与诺和灵30R组,每组各30例,在固定的糖尿病饮食及教育的基础上,采用每日2次早晚餐前皮下注射诺和锐30或诺和灵30R。观察两组不同治疗方案患者空腹血糖（FPG）、餐后2h血糖（2hPBG）、糖化血红蛋（HbA1c）、住院时间、胰岛素计量变化及低血糖发生情况。结果①两组治疗后FPG和2hpBG均明显下降（P〈0.01）,但诺和锐30组餐后血糖下降更明显（P〈0.05）;②诺和锐30组住院时间较诺和灵30R组明显缩短（P〈0.01）;③诺和锐30组在控制血糖更佳的同时全天所需药物剂量较诺和灵30R组减少约10%（P〈0.01）;④诺和锐30组低血糖发生率明显低于诺和灵30R组（P〈0.05）。结论诺和锐30能更好的降低2型糖尿病血糖水平,而不增加低血糖的风险,能减少胰岛素的用量,并能缩短患者住院时间节省住院费用。

The clinical study to treatment of newly diagnosed type 2 diabetes with BIAsp 30 and BHI 30

Objective To compare the clinical curative effects of treatment of newly diagnosed type 2 diabetes with Biphasic Insulin Aspart 30 （BIAsp30） and BHI30.Methods 60 patients newly diagnosed type 2 diabetes patients were randomly divided into two groups（BIAsp30 groups and BHI30 groups）,30 cases in each of the diabetes mellitus dietary and fixed on the basis of education,2 times a day early before dinner and sharpness hypodermic and BIAsp 30 or BHI30r.Observe two different treatments with fasting plasma glucose （FPG） and postprandial 2 hours glucose （two hours 2hPBG）,HbA1c,length of inhospital stay,and changes in insulin hypoglycemia measuring conditions.Results ①two groups 2hpBG and FPG namely after treatment were obviously decreased （P0.01）,but the group of BIAsp30 and sharpness of postprandial glucose down more obvious （P0.05）;②and BIAsp30 groups and spirit recoered more significantly reduced BHI30 group （P0.01）;③and BIAsp30 groups in controlling blood sugar is better at the same time is needed to all doses and BHI30 approximately 10% reduction group （P0.01）;④and significantly lower incidence of hypoglycemia BIAsp30 groups than BHI30 group （P0.05）.Conclusion BIAsp 30 can better reduce blood glucose levels in type 2 diabetes,but not increase the risk of hypoglycaemia,can reduce the dosage of insulin,and can shorten the time of hospitalization and expenses saving in hospital.