Antioxidant marine algae phlorotannins and radioprotection: A review of experimental evidence |
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| Authors: | Taekyun Shin Meejung Ahn Jin Won Hyun Sung Ho Kim Changjong Moon |
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| Affiliation: | 1. Laboratory of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 690-756, South Korea;2. Institute for Nuclear Science and Technology, Jeju National University, Jeju 690-756, South Korea;3. College of Medicine, Jeju National University, Jeju 690-756, South Korea;4. Department of Biochemistry, College of Medicine, Jeju National University, Jeju 690-756, South Korea;5. Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, South Korea |
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| Abstract: | Radiation has been widely used for cancer therapy in human medicine. However, the side effects of radiation are problematic and can limit its application. Radiation generates reactive oxygen species, leading to cell death via multiple signaling pathways. The blocking of certain signaling cascades using antioxidants represents a compensatory therapy of radiation-induced tissue injury. Although synthetic chemicals have been investigated in recent decades, anti-oxidants from natural resources have been searched for continuously. Among them, phlorotannins from marine algae, including Ecklonia cava, have been shown to protect cells from radiation-induced injury as well as oxidative stress. In the present review, the radioprotective capacity of phlorotannins derived from marine algae and the mechanisms involved are discussed. |
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