Cholesterol metabolism in hypertriglyceridaemia and the effects of treatment. |
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Authors: | L A Simons N B Myant |
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Institution: | 1. Department of Medicine, University of New South Wales and Lipid Clinic, St. Vincent''s Hospital, Darlinghurst, N.S.W. 2010 Australia;2. M.R.C. Lipid Metabolism Unit, Hammersmith Hospital, London W12 0HS U.K. |
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Abstract: | The faecal output of bile acids and endogenous neutral steroids was increased in three hypertriglyceridaemic patients. One patient had familail type IIb, one had type IV and the third had type V hyperlipoproteinaemia. The hyperlipidaemia in the type IV and type V patients was associated with diabetes and a high alcohol intake. The plasma cholesterol and triglyceride concentrations and the faecal output of bile acids decreased significantly when the type IIb patient was given D-thyroxine plus propranolol, and when the type IV and type V patients were treated by withdrawal of alcohol, a low=carbohydrate diet and insulin or glibenclamide. The findings are discussed in relation to the possibility that hypertriglyceridaemia and increased bile acid synthesis in these patients have a common metabolic origin. |
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Keywords: | Reprint requests and correspondence: Dr L A Simons Medical Professorial Unit St Vincent's Hospital Darlinghurst N S W 2010 Australia |
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